Chemokine‐Induced Leishmanicidal Activity in Murine Macrophages via the Generation of Nitric Oxide
نویسندگان
چکیده
منابع مشابه
Chemokine-induced leishmanicidal activity in murine macrophages via the generation of nitric oxide.
This study explored the role of the proinflammatory chemokines macrophage inflammatory protein (MIP)-1alpha and macrophage chemoattractant protein (MCP)-1 for development of antileishmanial activity. There was substantial inhibition in nitrite generation in Leishmania donovani-infected macrophages. A marked elevation of nitrite generation and induction of inducible nitric oxide (NO) synthase (i...
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In the present investigation, the effects of melatonin on the generation of nitric oxide in stimulated murine macrophages were studied by electron paramagnetic resonance techniques, and the underlying mechanisms were discussed. Upon stimulation with lipopolysaccharide/interferon-gamma, macrophages generated a high concentration of nitric oxide. Melatonin pretreatment significantly inhibited the...
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The role of nitric oxide (NO) in the pathophysiology of gram-positive sepsis is uncertain. In inflammatory conditions, high-output NO production is catalyzed by the enzyme inducible nitric oxide synthase (iNOS). The ability of 2 strains of pneumococci, pneumococcal cell wall preparations, and purified pneumococcal capsule (Pnu-Imune 23) to trigger the production of iNOS protein and NO in RAW 26...
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Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whethe...
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We examined the expression and activity of inducible nitric oxide synthase (iNOS) in both gamma interferon (IFN-gamma)-treated and untreated murine macrophages infected with the gram-negative bacterium Brucella suis. The bacteria were opsonized with a mouse serum containing specific antibrucella antibodies (ops-Brucella) or with a control nonimmune serum (c-Brucella). The involvement of the pro...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2002
ISSN: 0022-1899,1537-6613
DOI: 10.1086/340820